Stabilization of Aqueous Hemin Solutions.

Protein thermal stabilization in aqueous solutions of osmolytes.

Proteins' thermal stabilization is a significant problem in various biomedical, biotechnological, and technological applications. We investigated thermal stability of hen egg white lysozyme in aqueous solutions of the following stabilizing osmolytes: Glycine (GLY), N-methylglycine (NMG), N,N-dimethylglycine (DMG), N,N,N-trimethylglycine (TMG), and trimethyl-N-oxide (TMAO). Results of CD-UV spec...

Physical stabilization of proteins in aqueous solution.

The formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native secondary and higher order structures necessary for biological activity (Cleland et al., 1993; Manning et al., 1989). Denaturation, as it is defined in this context, will be any non-native ...

Solid aqueous solutions

In most treatments of aqueous "solutions" it is taken for granted that water is present in the liquid state and in excess, with the concentrations of solutes limited by their saturation solubilities. Hence, the thermodynamic reference states are defined as the infinitely dilute solution, a solution of unit molality, etc. In recent years supersaturated aqueous solutions have been receiving incre...

Aqueous Solutions of Deuterium Oxide

The differences between the boiling points of dilute aqueous solutions of heavy water and the boiling point of ordinary water were measured in the range from 0.3 to 7 percent of D 20. The boiling points were found to increase linearly with increase in D 20, according to the equation mole % of D20 = 70.9 (tJ.T), where tJ.T is the boiling point in degrees centigrade minus 100. The measmements, ma...

Explosivity Conditions of Aqueous Solutions